Feasibility of radioactive embolization of intracranial aneurysms using 32P-implanted coils.

Jean Raymond, Philippe Leblanc, Anick Lambert, Stavros A Georganos, François Guilbert, Christian Janicki, Sjoerd Roorda

Journal: Stroke 2003;34(4):1035-7

PMID: 12649516

Abstract

BACKGROUND AND PURPOSE

Beta radiation can prevent recanalization after embolization. Our goal was to assess the feasibility of endovascular treatment of intracranial aneurysms using coils of a predetermined activity of 32P per centimeter.

METHODS

We studied the total length of coils deployed into 357 intracranial aneurysms. Aneurysmal volumes were estimated using 3 mathematical models. We simulated that coils were implanted with 0.26 microCi/cm of 32P, calculated resulting volumetric activities, and compared them with "effective" levels derived from experimental data and "safe" levels prescribed for the clinical use of 32P in cystic craniopharyngiomas.

RESULTS

Effective activities would have been reached in 92% to 98% of lesions had the coils been radioactive at the time of treatment.

CONCLUSIONS

Radioactive coil embolization of aneurysms is feasible in most patients.

Address: Department of Radiology, Research Centre of Centre Hospitalier de l'Université de Montréal, Québec, Canada. [email protected]

DOI: 10.1161/01.STR.0000063140.00091.A6

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MeSH Terms: Adult, Aged, Beta Particles, Combined Modality Therapy, Embolization, Therapeutic, Feasibility Studies, Female, Humans, Intracranial Aneurysm, Male, Middle Aged, Models, Theoretical, Phosphorus Radioisotopes, Prostheses and Implants, Retrospective Studies