The switch from pRb/p105 to Rb2/p130 in DNA damage and cellular senescence.

Heike Helmbold, Umberto Galderisi, Wolfgang Bohn

Journal: Journal of cellular physiology 2012;227(2):508-13

PMID: 21465484

Abstract

Cellular senescence is a response to genotoxic stress that results in an irreversible cell cycle arrest. Activation of this pathway relies on the activity of the retinoblastoma proteins and proteins of the DNA damage response cascade. Here, we discuss the functional relevance of the switch from pRb/p105 to Rb2/p130 that becomes apparent when cells enter senescent arrest.

Address: Department of Tumorvirology, Heinrich-Pette-Institute, Leibniz-Institute for Experimental Virology, Hamburg, Germany.

DOI: 10.1002/jcp.22786

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MeSH Terms: Cell Cycle, Cell Cycle Proteins, Cellular Senescence, DNA Damage, Gene Expression Regulation, Humans, Nuclear Proteins, Repressor Proteins, Retinoblastoma-Like Protein p130