Magnetoresistive-based biosensors and biochips.

Daniel L Graham, Hugo A Ferreira, Paulo P Freitas

Journal: Trends in biotechnology 2005;22(9):455-62

PMID: 15331226

Abstract

Over the past five years, magnetoelectronics has emerged as a promising new platform technology for biosensor and biochip development. The techniques are based on the detection of the magnetic fringe field of a magnetically labeled biomolecule interacting with a complementary biomolecule bound to a magnetic-field sensor. Magnetoresistive-based sensors, conventionally used as read heads in hard disk drives, have been used in combination with biologically functionalized magnetic labels to demonstrate the detection of molecular recognition. Real-world bio-applications are now being investigated, enabling tailored device design, based on sensor and label characteristics. This detection platform provides a robust, inexpensive sensing technique with high sensitivity and considerable scope for quantitative signal data, enabling magnetoresistive biochips to meet specific diagnostic needs that are not met by existing technologies.

Address: Institute of Engineering of Systems and Computers-Microsystems and Nanotechnologies (INESC-MN), Rua Alves Redol 9, Lisbon 1000-029, Portugal. [email protected]

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