Changes in tissue factor and activated factor XII following an acute myocardial infarction were uninfluenced by high doses of n-3 polyunsaturated fatty acids.

Heidi Grundt, Øyvind Hetland, Dennis W T Nilsen

Journal: Thrombosis and haemostasis 2003;89(4):752-9

PMID: 12669132

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Abstract

Few data exist on the effects of n-3 polyunsaturated fatty acids (PUFAs) on the initiators and endstage products of coagulation following an acute myocardial infarction (MI). We assessed the long-term effects of n-3 PUFAs on postinfarct variations of tissue factor (TF), activated factor XII (FXIIa) and fibrin monomer (FM), and expected additional statin treatment to modify thrombogenicity. Acute MI patients (n = 300) were randomly allocated to a high dose of n-3 PUFAs or corn oil for at least one year. Plasma concentrations of TF, FXIIa and FM were unaffected by n-3 PUFAs as compared to corn oil, and were uninfluenced by additional statin treatment in subgroup analyses. TF decreased (p = 0.0001), while FXIIa increased during the first 6 weeks (p = 0.001). FM remained essentially unchanged during the entire observation period. In conclusion, TF, FXIIa and FM were unaffected by long-term treatment with high- dosed n-3 PUFAs and by additional statin treatment.

Address: Department of Medicine, Central Hospital in Rogaland, POB 8100, 4068 Stavanger, Norway. [email protected]

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MeSH Terms: Acute Disease, Adult, Aged, Aged, 80 and over, Blood Coagulation, Cholesterol, Corn Oil, Double-Blind Method, Factor XIIa, Fatty Acids, Omega-3, Fatty Acids, Unsaturated, Female, Fibrin, Humans, Lipid Metabolism, Male, Middle Aged, Models, Statistical, Myocardial Infarction, Prospective Studies, Random Allocation, Thromboplastin, Triglycerides