Mg2+ homeostasis: the Mg2+nificent TRPM chanzymes.

Craig Montell

Journal: Current biology : CB 2004;13(20):R799-801

PMID: 14561419

Free Full Text on Elsevier Science View on PubMed

Abstract

TRPM6 and TRPM7 are distinct from all other ion channels in that they are composed of linked channel and protein kinase domains. Recent studies demonstrate that these 'chanzymes' are essential for Mg(2+) homeostasis, which is critical for human health and cell viability.

Address: Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA. [email protected]

DOI: 10.1016/j.cub.2003.09.048

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https://assays.cancer.gov/non-CPTAC-4068

MeSH Terms: Homeostasis, Humans, Ion Channels, Magnesium, Protein Conformation, Protein Kinases, TRPM Cation Channels