Improvement of diabetic autonomic gustatory sweating by botulinum toxin type A.

D A Restivo, S Lanza, F Patti, S Giuffrida, R Marchese-Ragona, P Bramanti, A Palmeri

Journal: Neurology 2003;59(12):1971-3

PMID: 12499494

Abstract

Fourteen diabetic subjects with gustatory sweating were treated by intracutaneous injections of botulinum toxin type A into the affected facial skin areas. In all subjects, sweating (measured by Minor starch iodine test) ceased within 4 days, with the maximal follow-up time lasting 24 weeks. This therapeutic approach, which could be used to reduce the severity of diabetic gustatory sweating, appears to be long lasting, adverse effect free, and minimally invasive.

Address: Department of Physiological Sciences, University of Catania, Italy.

DOI: 10.1212/01.wnl.0000036911.75478.fa

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MeSH Terms: Aged, Autonomic Nervous System Diseases, Botulinum Toxins, Diabetes Complications, Electrophysiology, Female, Humans, Iodine, Male, Middle Aged, Parasympathetic Fibers, Postganglionic, Starch, Sweating, Gustatory