Genetic code: introducing pyrrolysine.

Dieter Söll, Michael Ibba

Journal: Current biology : CB 2003;12(13):R464-6

PMID: 12121639

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Abstract

Monomethylamine methyltransferase of the archaebacterium Methanosarcina barkeri contains a novel amino acid, pyrrolysine, encoded by the termination codon UAG. Initial studies suggest that pyrrolysine may be co-translationally inserted during protein synthesis, probably by a mechanism analogous to that operating during selenocysteine incorporation.

Address: Department of Microbiology, The Ohio State University, 484 West 12th Avenue, Columbus 43210-1292, USA.

DOI: 10.1016/s0960-9822(02)00947-8

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MeSH Terms: Amino Acyl-tRNA Synthetases, Archaeal Proteins, Codon, Genes, Archaeal, Lysine, Methanosarcina barkeri, Methyltransferases, Protein Biosynthesis