The mechanism(s) of hypoxic pulmonary vasoconstriction: potassium channels, redox O(2) sensors, and controversies.

Stephen Archer, Evangelos Michelakis

Journal: News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society 2002;17():131-7

PMID: 12136039

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Abstract

Hypoxic pulmonary vasoconstriction matches perfusion to ventilation and optimizes systemic oxygenation. Alterations in PO(2) are sensed by a vascular redox O(2) sensor in the pulmonary artery smooth muscle cell, probably within the mitochondria. This creates a signal that modulates redox-sensitive K(+) channels, thereby controlling membrane potential, Ca(2+) entry, and tone.

Address: Department of Medicine (Cardiology) and the Vascular Biology Group, University of Alberta, Edmonton, Alberta T6G 2B7, Canada.

DOI: 10.1152/nips.01388.2002

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MeSH Terms: Chemoreceptor Cells, Humans, Hypoxia, Oxidation-Reduction, Oxygen, Potassium Channels, Pulmonary Circulation, Vasoconstriction