Skin aging: postulated mechanisms and consequent changes in structure and function.

B A Gilchrest, M Yaar

Journal: Clinics in geriatric medicine 2001;17(4):617-30, v

PMID: 11535419

Full Text on Elsevier Science View on PubMed

Abstract

Aging is a complex process influenced by telomere shortening and damage to cellular DNA. New insights into age-associated decrements in DNA damage repair are reviewed. Age-associated gross, histologic, and functional cutaneous deficits are delineated. Different treatment options for aged skin are examined.

Address: Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts 02118, USA.

DOI: 10.1016/s0749-0690(05)70089-6

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MeSH Terms: Antioxidants, DNA Damage, DNA Repair, Diet, Hormone Replacement Therapy, Humans, Hydroxy Acids, Keratolytic Agents, Skin Aging, Smoking, Sunscreening Agents, Tretinoin