Chemoprevention of colorectal cancer: slow, steady progress.

Carol A Burke, William M Bauer, Bret Lashner

Journal: Cleveland Clinic journal of medicine 2003;70(4):346-50

PMID: 12701989

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Abstract

In population-based observational studies, people had lower rates of colorectal cancer if they were taking various agents, including nonsteroidal anti-inflammatory drugs, calcium, and folate. In placebo-controlled trials in patients with familial adenomatous polyposis and in patients with sporadic colon adenomas, nonsteroidal anti-inflammatory drugs reduced the rates of adenomas, and there is a biologic rationale that they would be effective in reducing colorectal cancer as well. Randomized trials of chemopreventive agents are underway in the general population.

Address: Department of Gastroenterology, The Cleveland Clinic, Cleveland Clinic Foundation, OH 44195, USA. [email protected]

DOI: 10.3949/ccjm.70.4.346

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https://medlineplus.gov/colorectalcancer.html

MeSH Terms: Adenomatous Polyposis Coli, Anti-Inflammatory Agents, Non-Steroidal, Antineoplastic Agents, Aspirin, Celecoxib, Colorectal Neoplasms, Folic Acid, Humans, Pyrazoles, Sulfonamides, Sulindac