The adaptive regulation of amino acid transport system A is associated to changes in ATA2 expression.

R F Gazzola, R Sala, O Bussolati, R Visigalli, V Dall'Asta, V Ganapathy, G C Gazzola

Journal: FEBS letters 2001;490(1-2):11-4

PMID: 11172802

Abstract

The activity of transport system A for neutral amino acids is adaptively stimulated upon amino acid starvation. In cultured human fibroblasts this treatment causes an increase in the expression of the ATA2 system A transporter gene. ATA2 mRNA increase and transport stimulation are suppressed by system A substrates, but they are unaffected by other amino acids. Supplementation of amino acid-starved cells with substrates of system A causes a decrease in both ATA2 mRNA and system A transport activity. These results suggest a direct relationship between ATA2 expression and system A transport activity.

Address: Department of Experimental Medicine, University of Parma, Via Volturno 39, 43100 Parma, Italy.

DOI: 10.1016/s0014-5793(01)02126-3

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MeSH Terms: Amino Acid Transport Systems, Blotting, Northern, Carrier Proteins, Cell Line, Culture Media, Fibroblasts, Humans, Proline, Protein Transport, RNA, Messenger, Time Factors