HMG1 and 2, and related 'architectural' DNA-binding proteins.

J O Thomas, A A Travers

Journal: Trends in biochemical sciences 2001;26(3):167-74

PMID: 11246022

Full Text on Elsevier Science View on PubMed

Abstract

The HMG-box proteins, one of the three classes of high mobility group (HMG) chromosomal proteins, bend DNA and bind preferentially to distorted DNA structures. The proteins appear to act primarily as architectural facilitators in the assembly of nucleoprotein complexes; for example, in effecting recombination and in the initiation of transcription. HMG-box proteins might be targeted to particular DNA sites in chromatin by either protein-protein interactions or recognition of specific DNA structures.

Address: Cambridge Centre for Molecular Recognition, University of Cambridge, 80 Tennis Court Road, Cambridge, UK CB2 1GA. [email protected]

DOI: 10.1016/s0968-0004(01)01801-1

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MeSH Terms: Amino Acid Sequence, DNA-Binding Proteins, High Mobility Group Proteins, Humans, Molecular Sequence Data, Protein Conformation, Sequence Homology, Amino Acid