Bordetella pertussis, molecular pathogenesis under multiple aspects.

R Antoine, C Locht, F Jacob-Dubuisson

Journal: Current opinion in microbiology 2001;4(1):82-9

PMID: 11173039

Abstract

Recent studies, including those based on genomics, have demonstrated that besides toxins and adhesins, Bordetella pertussis uses many additional virulence determinants. Most of them are part of the BvgAS regulon, although some, in particular iron-uptake systems, are independent of BvgAS. They are regulated by iron, although in one case, the production of a siderophore receptor could be linked to the BvgAS regulon.

Address: INSERM U447, Institut Pasteur de Lille, 1 rue du Prof. Calmette, F-59019, Lille Cedex, France. [email protected]

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