Metabolic engineering of isoprenoids.

R Barkovich, J C Liao

Journal: Metabolic engineering 2001;3(1):27-39

PMID: 11162230

Full Text on Elsevier Science View on PubMed

Abstract

The metabolic engineering of natural products has begun to prosper in the past few years due to genomic research and the discovery of biosynthetic genes. While the biosynthetic pathways and genes for some isoprenoids have been known for many years, new pathways have been found and known pathways have been further investigated. In this article, we review the recent advances in metabolic engineering of isoprenoids, focusing on the molecular genetics that affects pathway engineering the most. Examples in mono- sequi-, and diterpenoid synthesis as well as carotenoid production are discussed.

Address: Department of Chemical Engineering, University of California, Los Angeles, California 90095, USA.

DOI: 10.1006/mben.2000.0168