Intervening in atherogenesis: lessons from diabetes.

H Vlassara

Journal: Hospital practice (1995) 2000;35(11):25-7, 32, 35-9

PMID: 11108004

Abstract

Age-related atherogenesis resembles diabetes, a model in which glucose looms as an important culprit. Within the body, the sugar becomes a glue able to harden and obstruct blood vessels while also activating such cells as macrophages and T lymphocytes. A new discovery is that large quantities of glycation endproducts may arrive preformed in foods prepared by routine cooking methods.

Address: Division of Experimental Diabetes and Aging, Mount Sinai School of Medicine, New York, N.Y., USA.

DOI: 10.3810/hp.2000.11.218

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MeSH Terms: Arteriosclerosis, Cooking, Diabetes Mellitus, Diet, Atherogenic, Enzyme Inhibitors, Glucose, Glycation End Products, Advanced, Guanidines, Humans, Models, Biological