Variability and regulation of O6-alkylguanine-DNA alkyltransferase.

Geoffrey P Margison, Andrew C Povey, Bernd Kaina, Mauro F Santibáñez Koref

Journal: Carcinogenesis 2003;24(4):625-35

PMID: 12727789

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Abstract

O(6)-Alkylguanine-DNA alkyltransferase (ATase) confers resistance to many of the biological effects of certain classes of alkylating agents by repairing the DNA lesions responsible. The role of ATase in the mutagenic and toxic effects of the carcinogenic and antitumour alkylating agents are of interest in relation to the prevention and treatment of cancer in man. In this commentary we specifically focus on the variation in ATase levels and our current understanding of the factors involved in the regulation of ATase expression.

Address: Cancer Research Uk Carcinogenesis Group, Paterson Institute for Cancer Research, Manchester M20 4BX, UK. [email protected]

DOI: 10.1093/carcin/bgg005

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MeSH Terms: Alkylation, Amino Acid Sequence, Chromatin, DNA, Humans, Molecular Sequence Data, O(6)-Methylguanine-DNA Methyltransferase, Phosphorylation, Promoter Regions, Genetic, Sequence Homology, Amino Acid, Transcription Factors