Cardiac adrenergic innervation within the first 3 months after acute myocardial infarction.

S Simula, T Lakka, J Kuikka, T Laitinen, J Remes, R Kettunen, J Hartikainen

Journal: Clinical physiology (Oxford, England) 2000;20(5):366-73

PMID: 10971548

Abstract

It is widely accepted that myocardial infarction results in adrenergic denervation of the infarcted and peri-infarcted myocardium. On the contrary, the concept of re-innervation of adrenergic nerve fibres is less well established. Although there is evidence of partial re-innervation occuring several months after myocardial infarction, the extent and time scale of re-innervation are only poorly known. In this study we investigated changes in cardiac adrenergic innervation and myocardial perfusion during the early convalescence period (the first 3 months) after an acute myocardial infarction. Single-photon emission computed tomographic imaging was conducted in 15 men 1 week and 3 months after an acute myocardial infarction with I123-metaiodobentzylguanidine (MIBG) and Tc99m-sestamibi (MIBI) to determine the extent of adrenergic denervation and impaired perfusion, respectively. A MIBG and MIBI defect was determined as regional uptake

Address: Department of Medicine, Kuopio University Hospital, Kuopio, Finland.

DOI: 10.1046/j.1365-2281.2000.00278.x

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MeSH Terms: 3-Iodobenzylguanidine, Adrenergic Fibers, Adult, Aged, Chronic Disease, Electrocardiography, Follow-Up Studies, Heart, Humans, Image Processing, Computer-Assisted, Iodine Radioisotopes, Male, Middle Aged, Muscle Denervation, Myocardial Infarction, Myocardial Reperfusion, Technetium Tc 99m Sestamibi, Thrombolytic Therapy, Time, Tomography, Emission-Computed, Single-Photon