Discovery of the ceruloplasmin homologue hephaestin: new insight into the copper/iron connection.

R S Eisenstein

Journal: Nutrition reviews 2000;58(1):22-6

PMID: 10697391

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Abstract

Approximately 75 years ago Hart and colleagues discovered that copper deficiency impaired mammalian iron metabolism. Discovery of hephaestin identifies a critical new component of the copper and iron connection in mammals. Hephaestin appears to be a multicopper oxidase required for efficient export of iron from the intestine.

Address: Department of Nutritional Sciences, University of Wisconsin, Madison 53706, USA.

DOI: 10.1111/j.1753-4887.2000.tb01821.x

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MeSH Terms: Ceruloplasmin, Copper, Humans, Intestinal Absorption, Iron, Membrane Proteins