Dyslipidemia is associated with sarcopenia of the elderly: a meta-analysis.

Bingqing Bi, Xinying Dong, Meilin Yan, Zhuo Zhao, Ruitong Liu, Shugang Li, Hao Wu

Journal: BMC geriatrics 2024;24(1):181

PMID: 38395763

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Plain Language Summary

Sarcopenia is a condition where older individuals experience a gradual loss of muscle mass and strength and this may be associated with elevated blood lipids levels, increasing the risk of developing cardiovascular diseases. This meta-analysis included twenty case-controlled studies investigating the association between dyslipidemia and sarcopenia and the difference in lipid profile in sarcopenia and non-sarcopenia. The results of this study showed a positive association between sarcopenia and dyslipidemia. There was a difference in lipid levels between sarcopenia and non-sarcopenia and the difference in lipid profile in the elderly population was associated with age, sex and region. Healthcare professionals can use the results of this meta-analysis to understand the association between sarcopenia in elderly people with dyslipidemia, age, region and sex. Further high-quality studies are necessary to confirm causation due to the significant heterogeneity among the included studies.

Abstract

PURPOSE

Sarcopenia is a pathological change characterized by muscle loss in older people. According to the reports, there is controversy on the relationship between dyslipidemia and sarcopenia. Therefore, this meta-analysis aimed to explore the association between sarcopenia and dyslipidemia.

METHODS

We searched the Cochrane Library, Web of Science, PubMed, China National Knowledge Infrastructure (CNKI), Wan Fang, China Science and Technology Journal Database (VIP Database) for case‒control studies to extract data on the odds ratio (OR) between sarcopenia and dyslipidemia and the MD(mean difference) of TC, LDL-C, HDL-C, TG, and TG/HDL-C between sarcopenia and nonsarcopenia. The JBI(Joanna Briggs) guidelines were used to evaluate the quality. Excel 2021, Review Manager 5.3 and Stata 16.0 were used for the statistical analysis.

RESULTS

Twenty studies were included in the meta-analysis, 19 of which were evaluated as good quality. The overall OR of the relationship between sarcopenia and dyslipidemia was 1.47, and the MD values of TC, LDL-C, HDL-C, TG, and TG/HDL-C were 1.10, 1.95, 1.27, 30.13, and 0.16 respectively. In female, compared with the non-sarcopnia, the MD of TC, LDL-C, HDL-C, TG of sarcopenia were - 1.67,2.21,1.02,-3.18 respectively. In male, the MD of TC, LDL-C, HDL-C, TG between sarcopenia and non-sarcopenia were - 0.51, 1.41, 5.77, -0.67. The OR between sarcopenia and dyslipidemia of the non-China region was 4.38, and it was 0.9 in China. In the group(> 60), MD of TC between sarcopenia and non-sarcopenia was 2.63, while it was 1.54 in the group(20-60).

CONCLUSION

Dyslipidemia was associated with sarcopenia in the elderly, which was affected by sex, region and age.

Address: School of Public Health, Capital Medical University, Beijing, 100069, China.; School of Traditional Chinese Medicine, Capital Medical University, Beijing, 100069, China.; School of Public Health, Capital Medical University, Beijing, 100069, China. [email protected].; School of General Practice and Continuing Education, Capital Medical University, Beijing, 100069, China. [email protected].

DOI: 10.1186/s12877-024-04761-4