Vitamin D Levels in Women with Polycystic Ovary Syndrome: A Population-Based Study.

Johanna Lumme, Sylvain Sebert, Paula Pesonen, Terhi Piltonen, Marjo-Riitta Järvelin, Karl-Heinz Herzig, Juha Auvinen, Marja Ojaniemi, Maarit Niinimäki

Journal: Nutrients 2020;11(11):2831

PMID: 31752304

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Plain Language Summary

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. Literature suggests that vitamin D may have a role in improving reproductive and metabolic health in aﬀected women. The aim of this study was to evaluate vitamin D status in 31-year-old women with self-reported PCOS symptoms and/or diagnosed PCOS, compared with non-PCOS controls. The study is a prospective population-based study which analysed the vitamin D sample of 1,246 31-year old women. Results indicate that women with PCOS had increased levels of metabolic risk factors such as high body mass index and insulin resistance. However, despite these metabolic derangements, women with PCOS have an adequate vitamin D status compared with the controls. Authors conclude that women with PCOS showed no greater tendency to vitamin D insuﬃciency than the controls.

Abstract

BACKGROUND

Conflicting evidence supports a role for vitamin D in women with reproductive disorders such as polycystic ovary syndrome (PCOS) but studies on large, unselected populations have been lacking.

METHODS

We conducted a general population-based study from the prospective Northern Finland Birth Cohort 1966 (NFBC1966). Serum 25-hydroksyvitamin D (25(OH)D) levels were evaluated in women with self-reported PCOS ( = 280) versus non-symptomatic controls ( = 1573) at the age of 31 with wide range of endocrine and metabolic confounders.

RESULTS

The levels of 25(OH)D were similar among women with and without self-reported PCOS (50.35 vs. 48.30 nmol/L, = 0.051). Women with self-reported PCOS presented with a higher body mass index (BMI), increased insulin resistance, and low-grade inflammation and testosterone levels compared to controls. The adjusted linear regression model showed a positive association between total 25(OH)D levels in self-reported PCOS (β = 2.46, 95% confidence interval (CI) 0.84 to 4.08, = 0.003). The result remained after adjustment for BMI, testosterone, homeostatic model assessment of insulin resistance (HOMA-IR), and high-sensitivity C-reactive protein (hs-CRP) levels.

CONCLUSION

In this population-based setting, PCOS was associated with higher vitamin D levels when adjusting for confounding factors, without distinct beneficial effects on metabolic derangements.

Address: PEDEGO Research Unit (Research Unit for Pediatrics, Dermatology, Clinical Genetics, Obstetrics and Gynecology), University of Oulu, 90014 Oulu, Finland.; Medical Research Center Oulu (MRC Oulu), University of Oulu, 90014 Oulu, Finland.; Department of Obstetrics and Gynecology, Oulu University Hospital, 90220 Oulu, Finland.; Department of Pediatrics and Adolescence, Oulu University Hospital, 90220 Oulu, Finland.; Center for Life-Course Health Research, Faculty of Medicine, University of Oulu, 90014 Oulu, Finland.; Infrastructure for Population Studies, Faculty of Medicine, University of Oulu, 90014 Oulu, Finland.; Biocenter Oulu, University of Oulu, 90014 Oulu, Finland.; Department of Epidemiology and Biostatistics, MRC Centre for Environment and Health, School of Public Health, Imperial College, London W2 1PG, UK.; Department of Life Sciences, College of Health and Life Sciences, Brunel University London, Kingston Lane, Uxbridge, Middlesex UB8 3PH, UK.; Institute of Biomedicine, University of Oulu, 90014 Oulu, Finland.; Department of Gastroenterology and Metabolism, Poznan University of Medical Sciences, 61-701 Poznan, Poland.; Oulunkaari Health Center, 91100 Ii, Finland.

DOI: 10.3390/nu11112831

Patient Centred Factor

Antecedents: Vitamin D/PCOS

Clinical Imbalances

Hormonal

Laboratory Testing

Blood

Modifiable Lifestyle Factors

Diet

Nutrition Evidence Keywords

Insulin resistance BMI Obesity Body mass index Vitamin D Metabolic syndrome Cardiovascular disease Glucose metabolism Insulin sensitivity Adipose tissue Polycystic Ovary Syndrome PCOS

Bioactive Substances

Vitamin D

Link outs

Free resources

Full Text Sources:

Medical:

https://medlineplus.gov/polycysticovarysyndrome.ht...

Miscellaneous:

https://assays.cancer.gov/CPTAC-1478

Research Materials:

https://antibodies.cancer.gov/detail/CPTC-CRP-1

MeSH Terms: Adult, Biomarkers, Case-Control Studies, Female, Finland, Humans, Polycystic Ovary Syndrome, Prospective Studies, Risk Factors, Up-Regulation, Vitamin D