Infection in Chronic Inflammation and Gastrointestinal Cancer.

Lang Zha, Shari Garrett, Jun Sun

Journal: Diseases (Basel, Switzerland) 2019;7(1):28

PMID: 30857369

Plain Language Summary

Salmonella is a group of bacteria that is normally associated with food poisoning. In 2% to 5% of people with Salmonella food poisoning, the bacteria remain in the body, leading to long-term infection, which has been linked to various health problems. This literature review looked at the link between Salmonella infection and the development of diseases such as inflammatory bowel disease (IBD), gall bladder cancer and colon cancer. The authors describe how long-term Salmonella infection plays a role in several biological processes, such as stem cell maintenance, host cell transformation, and gut dysbiosis. Leaky gut, dysbiosis and inflammation are induced by the bacteria and contribute to the development of cancer. The authors conclude that more studies are needed to further understand the relationship between Salmonella infections and the risk of colon cancer.

Abstract

not only causes acute infections, but can also cause patients to become chronic "asymptomatic" carriers. has been verified as a pathogenic factor that contributes to chronic inflammation and carcinogenesis. This review summarizes the acute and chronic infection and describes the current research progress of infection contributing to inflammatory bowel disease and cancer. Furthermore, this review explores the underlying biological mechanism of the host signaling pathways manipulated by effector molecules. Using experimental animal models, researchers have shown that infection is related to host biological processes, such as host cell transformation, stem cell maintenance, and changes of the gut microbiota (dysbiosis). Finally, this review discusses the current challenges and future directions in studying infection and its association with human diseases.

Address: Division of Gastroenterology and Hepatology, Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA. [email protected].; Division of Gastroenterology and Hepatology, Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA. [email protected].; Division of Gastroenterology and Hepatology, Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA. [email protected].

DOI: 10.3390/diseases7010028