Epigenetics in the primary and secondary prevention of cardiovascular disease: influence of exercise and nutrition.
Andreas B Gevaert, Nathanael Wood, Jente R A Boen, Constantinos H Davos, Dominique Hansen, Henner Hanssen, Guido Krenning, Trine Moholdt, Elena Osto, Francesco Paneni, Roberto F E Pedretti, Torsten Plösch, Maria Simonenko, T Scott Bowen
Journal: European journal of preventive cardiology
2022;29(17):2183-2199
PMID: 35989414
Abstract
Increasing evidence links changes in epigenetic systems, such as DNA methylation, histone modification, and non-coding RNA expression, to the occurrence of cardiovascular disease (CVD). These epigenetic modifications can change genetic function under influence of exogenous stimuli and can be transferred to next generations, providing a potential mechanism for inheritance of behavioural intervention effects. The benefits of exercise and nutritional interventions in the primary and secondary prevention of CVD are well established, but the mechanisms are not completely understood. In this review, we describe the acute and chronic epigenetic effects of physical activity and dietary changes. We propose exercise and nutrition as potential triggers of epigenetic signals, promoting the reshaping of transcriptional programmes with effects on CVD phenotypes. Finally, we highlight recent developments in epigenetic therapeutics with implications for primary and secondary CVD prevention.
© The Author(s) 2022. Published by Oxford University Press on behalf of the European Society of Cardiology.
Address:
Research Group Cardiovascular Diseases, GENCOR Department, University of Antwerp, Campus Drie Eiken D.T.228, Universiteitsplein 1, Antwerp 2610, Belgium.; Department of Cardiology, Antwerp University Hospital (UZA), Edegem, Belgium.; School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK.; Research Group Cardiovascular Diseases, GENCOR Department, University of Antwerp, Campus Drie Eiken D.T.228, Universiteitsplein 1, Antwerp 2610, Belgium.; Cardiovascular Research Laboratory, Biomedical Research Foundation, Academy of Athens, Athens, Greece.; Department of Cardiology, Heart Center Hasselt, Jessa Hospital, Hasselt, Belgium.; BIOMED-REVAL-Rehabilitation Research Centre, Faculty of Rehabilitation Sciences, Hasselt University, Hasselt, Belgium.; Department of Sport, Exercise and Health, Sports and Exercise Medicine, Faculty of Medicine, University of Basel, Basel, Switzerland.; Laboratory for Cardiovascular Regenerative Medicine, Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.; Department of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian Institute of Science and Technology (NTNU), Trondheim, Norway.; Department of Women's Health, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.; Institute of Clinical Chemistry, University and University Hospital Zurich, Zurich, Switzerland.; University Heart Center, University Hospital Zurich, Zurich, Switzerland.; Laboratory of Translational Nutrition Biology, Swiss Federal Institute of Technology (ETH), Zurich, Switzerland.; University Heart Center, University Hospital Zurich, Zurich, Switzerland.; Center for Molecular Cardiology, University of Zurich, Zurich, Switzerland.; Department of Research and Education, University Hospital Zurich, Zurich, Switzerland.; Cardiovascular Department, IRCCS MultiMedica, Care and Research Institute, Milan, Italy.; Department of Obstetrics and Gynaecology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.; Perinatal Neurobiology, Department of Human Medicine, School of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, Oldenburg, Germany.; Physiology Research and Blood Circulation Department, Cardiopulmonary Exercise Test SRL, Federal State Budgetary Institution, 'V.A. Almazov National Medical Research Centre' of the Ministry of Health of the Russian Federation, Saint-Petersburg, Russian Federation.
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