Reward-related decision making in eating and weight disorders: A systematic review and meta-analysis of the evidence from neuropsychological studies.

Mudan Wu, Timo Brockmeyer, Mechthild Hartmann, Mandy Skunde, Wolfgang Herzog, Hans-Christoph Friederich

Journal: Neuroscience and biobehavioral reviews 2016;61():177-96

PMID: 26698021

Full Text on Elsevier Science View on PubMed

Abstract

Eating disorders (EDs) and overweight/obesity (OW/OB) are serious public health concerns that share common neuropsychological features and patterns of disturbed eating. Reward-related decision making as a basic neurocognitive function may trans-diagnostically underlie both pathological overeating and restricted eating. The present meta-analysis synthesizes the evidence from N=82 neuropsychological studies for altered reward-related decision making in all ED subtypes, OW and OB. The overall effect sizes for the differences between currently-ill ED patients and OW/OB people and controls were Hedge's g=-0.49 [CI: -0.63; -0.35], and Hedge's g=-0.39 [CI: -0.53; -0.25], respectively. Decision making was found to be altered to similar degrees in all ED subtypes and OB. Effect sizes, however, diverged for the different measures of decision making. Adolescents appear to be less affected than adults. When foods were used as rewarding stimuli, decision making was found to be intact in OB. The findings support that altered general reward-related decision making is a salient neuropsychological factor across eating and weight disorders in adulthood.

Address: Department of General Internal Medicine and Psychosomatics, University Hospital Heidelberg Heidelberg, Germany; Department of Psychology, College of Education, Shanghai Normal University, Shanghai, China.; Department of General Internal Medicine and Psychosomatics, University Hospital Heidelberg Heidelberg, Germany. Electronic address: [email protected].; Department of General Internal Medicine and Psychosomatics, University Hospital Heidelberg Heidelberg, Germany.; Department of General Internal Medicine and Psychosomatics, University Hospital Heidelberg Heidelberg, Germany; Department of Psychosomatic Medicine and Psychotherapy, LVR-Klinikum, University Duisburg-Essen, Essen, Germany.

DOI: 10.1016/j.neubiorev.2015.11.017