The Investigation on Resorcinarenes towards either Inhibiting or Promoting Insulin Fibrillation.

Xu Han, Chuan Tian, Ingrid Gandra, Valeria Eslava, Diana Galindres, Edgar Vargas, Roger Leblanc

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 2018;23(71):17903-17907

PMID: 29145692

Abstract

Different tail-engineered resorcinarenes have been examined for insulin fibrillation by experimental and computational studies. The resorcinarene showed a promising effect on the inhibition of insulin fibrillation, studied using a ThT assay, circular dichroism spectroscopy, and atomic force microscopy. Both the ThT assay and computational results indicate the tail from the resorcinarene has an impact on insulin fibrillation by either inhibition or promotion because of the resident position on insulin. These observations have significant biological implications in the design of drug molecules as well as the development of potential therapeutic strategies.

Address: Department of Chemistry, University of Miami, Coral Gables, FL, 33146, United States.; Department of Chemistry and Laufer Center for Physical and Quantitative Biology, Stony Brook University, Stony Brook, New York, 11794-3400, United States.; Florida International University, 10555 West Flagler Street, Miami, FL, 33174, United States.; Departamento de Quimica, Universidad de los Andes, Cr. 1, No. 18A 10, Bogota, 111711, Colombia.

DOI: 10.1002/chem.201704932

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https://doi.org/10.1002/chem.201704932

MeSH Terms: Calixarenes, Circular Dichroism, Dynamic Light Scattering, Humans, Insulin, Kinetics, Microscopy, Atomic Force, Molecular Dynamics Simulation, Phenylalanine, Spectrometry, Fluorescence, Water