Binding and crossing: Methods for the characterization of membrane-active peptides interactions with membranes at the molecular level.

Emmanuelle Sachon, Astrid Walrant, Sandrine Sagan, Sophie Cribier, Nicolas Rodriguez

Journal: Archives of biochemistry and biophysics 2021;699():108751

PMID: 33421380

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Abstract

Antimicrobial and cell-penetrating peptides have been the object of extensive studies for more than 60 years. Initially these two families were studied separately, and more recently parallels have been drawn. These studies have given rise to numerous methodological developments both in terms of observation techniques and membrane models. This review presents some of the most recent original and innovative developments in this field, namely droplet interface bilayers (DIBs), new fluorescence approaches, force measurements, and photolabelling.

Address: Sorbonne Université, École Normale Supérieure, PSL University, CNRS, Laboratoire des Biomolécules, LBM, 75005, Paris, France.; Sorbonne Université, École Normale Supérieure, PSL University, CNRS, Laboratoire des Biomolécules, LBM, 75005, Paris, France. Electronic address: [email protected].

DOI: 10.1016/j.abb.2021.108751

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MeSH Terms: Amino Acid Sequence, Antimicrobial Cationic Peptides, Cell Membrane, Cell-Penetrating Peptides, Fluorescent Dyes, Lipid Bilayers, Microscopy, Fluorescence, Photoaffinity Labels, Spectrometry, Fluorescence