Trace concentrations, heavy implications: Influences of biometals on major brain pathologies of Alzheimer's disease.

Stephen L P Lippi, Caroline L C Neely, Anthony L Amaya

Journal: The international journal of biochemistry & cell biology 2022;143():106136

PMID: 34906694

Full Text on Elsevier Science View on PubMed

Abstract

Alzheimer's disease (AD) is a neurodegenerative condition that involves accumulation of toxic protein species, notably amyloid-β (Aβ)plaques and neurofibrillary tau tangles that are associated with cognitive decline. These proteins can bind metal ions, ultimately affecting their structure and function. In this review, we discuss key biometals such as zinc, copper, and iron that interact with protein species involved in AD, mainly Aβ, tau, and the late-onset AD risk factor Apolipoprotein E (APOE). These metals interact with Aβ and tau proteins, affecting their aggregation and toxicity. The allele variants of APOE also have different interactions with these metals, affecting APOE protein expression and aggregation of AD protein species.

Address: Angelo State University, Department of Psychology, San Angelo, TX, USA. Electronic address: [email protected].; Massachusetts General Hospital, Department of Neurosurgery, Boston, MA, USA.; University of Texas at San Antonio, Department of Chemistry, San Antonio, TX, USA.

DOI: 10.1016/j.biocel.2021.106136

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MeSH Terms: Alzheimer Disease, Apolipoproteins E, Humans, Neurofibrillary Tangles, Trace Elements, tau Proteins