High-mechanical strength carboxymethyl chitosan-based hydrogel film for antibacterial wound dressing.

Mao Yang, Yanchun Li, Min Zhang, Meng Wai Woo, Wenjia Han, Xugang Dang

Journal: Carbohydrate polymers 2021;256():117590

PMID: 33483076

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Abstract

Hydrogels, being highly biocompatible and adaptable with biological tissues, have shown great usability in biomedical applications. In this research, a novel hydrogel film developed from carboxymethyl chitosan (CMCS) loaded with waterborne polyurethane-gelatin hydrolysate was synthesized via aqueous emulsion copolymerization. The synthesized hydrogel film was characterized using mechanical strength tests, FTIR, XPS, SEM, AFM, and various other analysis technologies. The results demonstrated that the hydrogel film exhibited good thermal stability, swelling behavior, as well as controllable biodegradability. Specifically, when the CMCS content was loaded at 6 %, the maximum tensile strength and elongation at the break of the hydrogel film were reached 31.69 MPa and 447.187, respectively. The disk diffusion tests indicated that the hydrogel film presented significant antibacterial activity against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). These results indicate that hydrogel films with high mechanical strength and high antibacterial activity could be used for wound dressing applications.

Address: School of Light Industry and Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250353, China.; School of Light Industry and Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250353, China. Electronic address: [email protected].; Department of Chemical & Materials Engineering, Faculty of Engineering, The University of Auckland, New Zealand.; Institute for Biomass and Function Materials & National Demonstration Centre for Experimental Light Chemistry Engineering Education, College of Bioresources Chemistry and Materials Engineering, Shaanxi University of Science and Technology, Xi'an, 710021, China. Electronic address: [email protected].

DOI: 10.1016/j.carbpol.2020.117590

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MeSH Terms: Anti-Bacterial Agents, Bandages, Biocompatible Materials, Biomass, Body Fluids, Chitosan, Emulsions, Escherichia coli, Gelatin, Humans, Hydrogels, Methylgalactosides, Polyurethanes, Spectroscopy, Fourier Transform Infrared, Staphylococcus aureus, Stress, Mechanical, Tensile Strength, Thermogravimetry, Water