Is there a dose response relationship for clodronate in the treatment of tumour induced hypercalcaemia?

S Shah, Janet Hardy, E Rees, J Ling, B Gwilliam, C Davis, K Broadley, R A'Hern

Journal: British journal of cancer 2002;86(8):1235-7

PMID: 11953878

Free Full Text on PubMed Central View on PubMed

Abstract

Eighty-six patients with tumour induced hypercalcaemia were randomised to 600, 900, 1200 or 1500 mg of intravenous clodronate, according to post hydration serum calcium levels. Sixty-seven were evaluable for response. The overall response rate was 49.3% (95% CI: 36.8-61.8) with no significant difference in response rates, i.e. achievement of normocalcaemia at days 6-9 (corrected serum calcium < or =2.6 mmol l(-1)) across all groups.

Address: Department of Palliative Medicine, The Royal Marsden NHS Trust, Sutton SM2 5PT, Surrey, UK.

DOI: 10.1038/sj.bjc.6600249

Link outs

Free resources

Full Text Sources:

Subscription / membership required

Full Text Sources:

https://doi.org/10.1038/sj.bjc.6600249

MeSH Terms: Adult, Aged, Aged, 80 and over, Calcium, Clodronic Acid, Dose-Response Relationship, Drug, Female, Humans, Hypercalcemia, Male, Middle Aged, Neoplasms