ERp57/PDIA3: new insight.

Silvia Chichiarelli, Fabio Altieri, Giuliano Paglia, Elisabetta Rubini, Marco Minacori, Margherita Eufemi

Journal: Cellular & molecular biology letters 2022;27(1):12

PMID: 35109791

Free Full Text on BioMed Central View on PubMed

Abstract

The ERp57/PDIA3 protein is a pleiotropic member of the PDIs family and, although predominantly located in the endoplasmic reticulum (ER), has indeed been found in other cellular compartments, such as the nucleus or the cell membrane. ERp57/PDIA3 is an important research target considering it can be found in various subcellular locations. This protein is involved in many different physiological and pathological processes, and our review describes new data on its functions and summarizes some ligands identified as PDIA3-specific inhibitors.

Address: Department of Biochemical Sciences "A.Rossi-Fanelli", Sapienza University of Rome, P.le A.Moro 5, 00185, Rome, Italy. [email protected].; Department of Biochemical Sciences "A.Rossi-Fanelli", Sapienza University of Rome, P.le A.Moro 5, 00185, Rome, Italy.; Enrico Ed Enrica Sovena" Foundation, Rome, Italy.

DOI: 10.1186/s11658-022-00315-x

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MeSH Terms: Cell Membrane, Cell Nucleus, Endoplasmic Reticulum, Protein Disulfide-Isomerases