Zinc ionophores: chemistry and biological applications.

Simone Scavo, Valentina Oliveri

Journal: Journal of inorganic biochemistry 2022;228():111691

PMID: 34929542

Full Text on Elsevier Science View on PubMed

Abstract

Zinc can play a pathophysiological role in several diseases and can interfere in key processes of microbial growth. This evidence justifies the efforts in applying Zinc ionophores to restore Zinc homeostasis and treat bacterial/viral infections such as coronavirus diseases. Zinc ionophores increase the intracellular concentration of Zinc ions causing significant biological effects. This review provides, for the first time, an overview of the applications of the main Zinc ionophores in Zinc deficiency, infectious diseases, and in cancer, discussing the pharmacological and coordination properties of the Zinc ionophores.

Address: Dipartimento di Scienze Chimiche, Università degli Studi di Catania, v.le A. Doria 6, 95125 Catania, Italy.; Dipartimento di Scienze Chimiche, Università degli Studi di Catania, v.le A. Doria 6, 95125 Catania, Italy. Electronic address: [email protected].

DOI: 10.1016/j.jinorgbio.2021.111691

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MeSH Terms: Acrodermatitis, Anti-Bacterial Agents, Antineoplastic Agents, Antiviral Agents, Communicable Diseases, Homeostasis, Humans, Ionophores, Neoplasms, Zinc, COVID-19 Drug Treatment