Vitamin E in the treatment of tardive dyskinesia: a meta-analysis.

Hongyan Xu, Haoqiang Qin, Shaohua Chen, Mingjian Guan

Journal: International clinical psychopharmacology 2022;37(2):60-66

PMID: 35045531

Abstract

Long-term use of antipsychotic drugs is associated with tardive dyskinesia. At present, there is no satisfactory treatment for tardive dyskinesia. Some randomized trials suggested that vitamin E can improve tardive dyskinesia. This study was undertaken to evaluate the effects of vitamin E treatment for tardive dyskinesia. We searched internet databases for randomized controlled trials. A total of 21 studies including 854 patients with tardive dyskinesia were included in this meta-analysis. Eighteen studies reported the Abnormal Involuntary Movements Scale (AIMS) as the primary outcome. After vitamin E treatment, a decrease of 2.36 (95% CI = -3.27 to -1.45; P < 0.00001) in the AIMS was observed in the treatment group, compared with the control group. Vitamin E may offer a new avenue treatment for tardive dyskinesia.

Address: Department of Neurology, People's Hospital of Wuzhou, Wuzhou, Guangxi.; Youjiang Medical University for Nationalities, Baise, China.

DOI: 10.1097/YIC.0000000000000387

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MeSH Terms: Antipsychotic Agents, Dyskinesia, Drug-Induced, Humans, Tardive Dyskinesia, Vitamin E