Syndromic obesity with neurodevelopmental delay: Opportunities for targeted interventions.

Tawakalitu Abosede Kehinde, Alisha Bhatia, Bukola Olarewaju, Muhammad Zain Shoaib, Jehan Mousa, Mayowa Azeez Osundiji

Journal: European journal of medical genetics 2022;65(3):104443

PMID: 35085835

Full Text on Elsevier Science View on PubMed

Abstract

Obesity is a growing public health problem in many developed countries, although similar trends are increasingly being described in some developing nations. The genetic underpinnings of obesity continue to arouse increasing research interests, investigations, and discussions. The recent advances in next generation sequencing technologies have shed some more light on the diverse monogenic and polygenic causes of obesity. Syndromic obesity due to chromosomal or monogenic defects has attendant co-morbidities, which may include neurodevelopmental delays, dysmorphism as well as organ-specific developmental anomalies. An improved understanding of the nature of neurodevelopmental challenges in syndromic obesity may pave the way for personalized dietary and physical activity management approaches. This review article describes the clinical and molecular genetic aspects of obesity-related syndromes and the associated neurodevelopmental disabilities. The potential opportunities for individualized nutrigenomic managements of syndromic obesity are also highlighted.

Address: Central and Northwest London NHS Foundation Trust, The Kingswood Centre, 134 Honeypot Lane, Kingsbury, London, NW9 0QY, United Kingdom.; Merit Academy, Santa Cruz, CA, 95063, USA.; Hammersmith and Charing Cross Hospital, Imperial College NHS Trust, United Kingdom.; Faculty of Life Sciences, McMaster University, Hamilton, ON, Canada.; Department of Clinical Genomics, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.; Division of Clinical and Metabolic Genetics, The Hospital for Sick Children, 555 University Avenue, University of Toronto, Toronto, ON, M5G1X8, Canada; Department of Clinical Genomics, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. Electronic address: [email protected].

DOI: 10.1016/j.ejmg.2022.104443

Link outs

Subscription / membership required

Full Text Sources:

MeSH Terms: High-Throughput Nucleotide Sequencing, Humans, Intellectual Disability, Obesity, Syndrome