The lead content of blood serum.

W I Manton, S J Rothenberg, M Manalo

Journal: Environmental research 2001;86(3):263-73

PMID: 11453677

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Abstract

Serum lead concentrations measured by stable isotope dilution with a thermal ionization mass spectrometer and blood lead concentrations measured by graphite furnace atomic absorption spectrophotometry are reported for 73 women of child bearing age resident in Los Angeles, California. The two quantities are related by the line y=0.00030+0.00241x (r=0.83), where y is serum lead concentration and x is blood lead concentration, both being expressed in units of microg/L. The linearity of the relationship appears to hold to a blood lead concentration of at least 60 microg Pb/L. The slope of the line indicates that lead in serum is 0.24% of that in whole blood in contrast to recent reports of between 0.32 and 0.35% determined by inductively coupled plasma (ICP) mass spectrometry with bismuth used as an internal standard. The discrepancy stems from the ICP mass spectrometer-generated curves not passing through the origin.

Address: Department of Geology, University of Texas at Dallas, Richardson, Texas 75083, USA.

DOI: 10.1006/enrs.2001.4271

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MeSH Terms: Adolescent, Adult, Female, Hemolysis, Humans, Iron, Lead, Linear Models, Mass Spectrometry, Metabolic Clearance Rate, Middle Aged, Mothers, Plasma, Reference Values, Reproducibility of Results, Spectrophotometry, Atomic, Statistical Distributions