Scintigraphy with [111In]octreotide and 201Tl in a Hürthle cell thyroid carcinoma without detectable radio-iodine uptake. Report of a case and review of the literature.

I Kostoglou-Athanassiou, A Pappas, L Gogou, P Kaldrymides

Journal: Hormone research 2004;60(4):205-8

PMID: 14530610

Full Text on S. Karger AG, Basel, Switzerland View on PubMed

Abstract

AIM

To describe the visualization of recurrent disease by [111In]octreotide and 201Tl scintigraphy in a patient with Hürthle cell thyroid carcinoma, increased thyroglobulin levels, and a negative radio-iodine total-body scan.

METHODS

Scintigraphy with [111In]octreotide and 201Tl was performed, and a local recurrence in the thyroid bed was detected which was excised by surgery.

RESULTS

On histology, the tumour proved to be a Hürthle cell carcinoma, and within the tumour somatostatin receptors were detected by RT-PCR.

CONCLUSION

Scintigraphy with [111In]octreotide and 201Tl is an alternative imaging method for the detection of residual disease in patients with a differentiated thyroid carcinoma having increased thyroglobulin levels and a negative radio-iodine total-body scan.

Address: Department of Endocrinology, Metaxa Hospital, Piraeus, Greece.

DOI: 10.1159/000073234

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MeSH Terms: Adenoma, Oxyphilic, Humans, Indium Radioisotopes, Iodine Radioisotopes, Male, Middle Aged, Neoplasm Recurrence, Local, Octreotide, Radionuclide Imaging, Receptors, Somatostatin, Thallium Radioisotopes, Thyroglobulin, Thyroid Neoplasms