Curcumin induces caspase-3-independent apoptosis in human multidrug-resistant cells.

Ewa Sikora, Katarzyna Piwocka, Anna Bielak-Mijewska

Journal: Annals of the New York Academy of Sciences 2003;973():250-4

PMID: 12485871

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Abstract

Curcumin, the major component of the spice turmeric, used in 50- micro M concentration, induced cell death in multidrug-resistant CEM(P-gp4) and LoVo(P-gp4) cells as well as in their sensitive counterparts as assessed by TUNEL method and morphological observation. In all cells induced to undergo cell death with curcumin, there was no caspase-3 activation because only the unprocessed form of caspase-3 was observed using immunoblotting.

Address: Laboratory of Molecular Bases of Aging, Nencki Institute of Experimental Biology, 3 Pasteur Street, 02-093 Warsaw, Poland. [email protected]

DOI: 10.1111/j.1749-6632.2002.tb04643.x

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MeSH Terms: Antineoplastic Agents, Apoptosis, Caspase 3, Caspases, Curcumin, Drug Resistance, Multiple, Humans, Tumor Cells, Cultured