The Role of High-density Lipoprotein in Oral and Dental Diseases.

Mohammad Bagherniya, Leila Sadeghalbanaei, Farinaz Shirban, Thozhukat Sathyapalan, Amirhossein Sahebkar

Journal: Current medicinal chemistry 2023;30(20):2226-2246

PMID: 36056865

Abstract

High-density lipoprotein (HDL) is the smallest and densest of the lipoproteins. Beyond its well-known cardiovascular protective function, it has other actions, including structural function, anti-inflammatory, antioxidant, anti-thrombotic effects, transport of bioactive molecules, and induction of signal transduction pathways. Further, there is a mutual connection between oral health and general health. Hence HDL could be a potentially crucial factor relating oral health to general health. As far as we know, no comprehensive study has been carried out to date, which has explored the association between HDL concentration and oral diseases including lichen plan, recurrent aphthous ulcers, candidiasis, implant osseointegration, oral cancer and precancerous conditions. Here in this review, we summarized the relationship between HDL and oral health, suggesting a significant association between HDL concentration and oral health.

Address: Department of Physiology and Pharmacology, Isfahan University of Medical Sciences, Isfahan, Iran.; Department of Pathology, Dental Research Institute, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.; Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.; Anesthesia and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.; Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.; Department of Diabetes and Endocrinology, Hull York Medical School, University of Hull, United Kingdom of Great Britain and Northern Ireland.; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.; Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.; School of Medicine, The University of Western Australia, Perth, Australia.; Department of Medical Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

DOI: 10.2174/0929867329666220901120654

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MeSH Terms: Humans, Lipoproteins, HDL, Lipoproteins, Stomatognathic Diseases, Cardiovascular Diseases