Therapeutic interventions target the NLRP3 inflammasome in ulcerative colitis: Comprehensive study.

Fares E M Ali, Islam M Ibrahim, Osama M Ghogar, Esraa K Abd-Alhameed, Hanan S Althagafy, Emad H M Hassanein

Journal: World journal of gastroenterology 2023;29(6):1026-1053

PMID: 36844140

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Abstract

One of the significant health issues in the world is the prevalence of ulcerative colitis (UC). UC is a chronic disorder that mainly affects the colon, beginning with the rectum, and can progress from asymptomatic mild inflammation to extensive inflammation of the entire colon. Understanding the underlying molecular mechanisms of UC pathogenesis emphasizes the need for innovative therapeutic approaches based on identifying molecular targets. Interestingly, in response to cellular injury, the NLR family pyrin domain containing 3 (NLRP3) inflammasome is a crucial part of the inflammation and immunological reaction by promoting caspase-1 activation and the release of interleukin-1β. This review discusses the mechanisms of NLRP3 inflammasome activation by various signals and its regulation and impact on UC.

Address: Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt.; Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt. [email protected].; Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt.; Pharmacology and Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 12345, Egypt.; Department of Biochemistry, Faculty of Science, University of Jeddah, Jeddah 12345, Saudi Arabia.

DOI: 10.3748/wjg.v29.i6.1026

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https://medlineplus.gov/ulcerativecolitis.html

MeSH Terms: Humans, Inflammasomes, Colitis, Ulcerative, NLR Family, Pyrin Domain-Containing 3 Protein, Inflammation, Colitis