Progresses in GluN2A-containing NMDA Receptors and their Selective Regulators.

Menghan Niu, Xin Yang, Yuanyuan Li, Yanping Sun, Long Wang, Jing Ha, Yinghua Xie, Zibin Gao, Changzheng Tian, Le Wang, Yongjun Sun

Journal: Cellular and molecular neurobiology 2023;43(1):139-153

PMID: 34978648

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Abstract

NMDA receptors play an important physiological role in regulating synaptic plasticity, learning and memory. GluN2A subunits are the most abundant functional subunits of NMDA receptors expressed in mature brain, and their dysfunction is related to various neurological diseases. According to subunit composition, GluN2A-containing NMDA receptors can be divided into two types: diheteromeric and triheteromeric receptors. In this review, the expression, functional and pharmacological properties of different kinds of GluN2A-containing NMDA receptors as well as selective GluN2A regulators were described to further understand this type of NMDA receptors.

Address: Department of Pharmacy, Hebei University of Science and Technology, Yuhua East Road 70, Shijiazhuang, 050018, Hebei, China.; Department of Pharmaceutical Engineering, Hebei Chemical & Pharmaceutical College, Fangxing Road 88, Shijiazhuang, 050026, Hebei, China.; Hebei Technological Innovation Center of Chiral Medicine, Shijiazhuang, China.; Hebei Research Center of Pharmaceutical and Chemical Engineering, Hebei University of Science and Technology, Shijiazhuang, China.; State Key Laboratory Breeding Base-Hebei Province Key Laboratory of Molecular Chemistry for Drug, Shijiazhuang, China.; Department of Family and Consumer Sciences, California State University, Long Beach, USA.; Department of Anesthesiology, The First Hospital of Hebei Medical University, Donggang Road 89, Shijiazhuang, 050000, Hebei, China. [email protected].; Department of Pharmaceutical Engineering, Hebei Chemical & Pharmaceutical College, Fangxing Road 88, Shijiazhuang, 050026, Hebei, China. [email protected].; Hebei Technological Innovation Center of Chiral Medicine, Shijiazhuang, China. [email protected].; Department of Pharmacy, Hebei University of Science and Technology, Yuhua East Road 70, Shijiazhuang, 050018, Hebei, China. [email protected].; Hebei Research Center of Pharmaceutical and Chemical Engineering, Hebei University of Science and Technology, Shijiazhuang, China. [email protected].; State Key Laboratory Breeding Base-Hebei Province Key Laboratory of Molecular Chemistry for Drug, Shijiazhuang, China. [email protected].

DOI: 10.1007/s10571-021-01185-1

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MeSH Terms: Receptors, N-Methyl-D-Aspartate, Neuronal Plasticity, Excitatory Amino Acid Antagonists