Endo-Lysosomal Two-Pore Channels and Their Protein Partners.

Sandip Patel, Spyros Zissimopoulos, Jonathan S Marchant

Journal: Handbook of experimental pharmacology 2023;278():199-214

PMID: 35902438

Abstract

Two-pore channels are ion channels expressed on acidic organelles such as the various vesicles that constitute the endo-lysosomal system. They are permeable to Ca and Na and activated by the second messenger NAADP as well as the phosphoinositide, PI(3,5)P and/or voltage. Here, we review the proteins that interact with these channels including recently identified NAADP receptors.

Address: Department of Cell and Developmental Biology, University College London, London, UK. [email protected].; Swansea University Medical School, Institute of Life Science, Swansea, UK.; Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI, USA.

DOI: 10.1007/164_2022_601

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https://dx.doi.org/10.1007/164_2022_601

MeSH Terms: Humans, Calcium Channels, Lysosomes, Calcium, Calcium Signaling