Epileptic Targets and Drugs: A Mini-Review.

Teresa Carolliny Moreira Lustoza Rodrigues, Jéssica Paiva de Moura, Aline Matilde Ferreira Dos Santos, Alex France M Monteiro, Simone Mendes Lopes, Marcus Tullius Scotti, Luciana Scotti

Journal: Current drug targets 2023;24(3):212-224

PMID: 36173074

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Abstract

BACKGROUND

Epilepsy is a neurological disease affected by an imbalance of inhibitory and excitatory signaling in the brain.

INTRODUCTION

In this disease, the targets are active in pathophysiology and thus can be used as a focus for pharmacological treatment.

METHODS

Several studies demonstrated the antiepileptic effect of drugs acting on the following targets: N-methyl-D-aspartate (NMDA), alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor, voltage-gated calcium channel (Cav), Gamma aminobutyric acid transporter type 1 (GAT1), voltage-gated sodium channels (Nav), voltage-gated potassium channel of the Q subfamily (KCNQ) and Gamma aminobutyric acid type A (GABAA) receiver.

RESULTS

These studies highlight the importance of molecular docking.

CONCLUSION

Quantitative Structure-Activity Relationship (QSAR) and computer aided drug design (CADD) in predicting of possible pharmacological activities of these targets.

Address: Federal University of Paraíba, Health Sci. Center, 50670-910, João Pessoa, PB, Brazil.; Teaching and Research Management, University Hospital, Federal University of Paraíba, João Pessoa, PB, Brazil.

DOI: 10.2174/1389450123666220927103715

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MeSH Terms: Humans, Molecular Docking Simulation, Epilepsy, Receptors, AMPA, Anticonvulsants, gamma-Aminobutyric Acid