Organoid Models of Heart Diseases: Find a New Channel in Improvements of Cardiac Regenerative Medicine.

Lakshmi Thangavelu, Saade Abdalkareem Jasim, Fahad Alsaikhan, Supat Chupradit, Wanich Suksatan, Dmitry Olegovich Bokov, Mohammed Abed Jawad, Satish Kumar Sharma

Journal: Current medicinal chemistry 2023;30(33):2726-3742

PMID: 36281859

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Abstract

We are experiencing a revolution in regenerative medicine. Recent developments in organoid technology have provided unique opportunities for studying human biology and diseases. Indeed, organoid models have revolutionized the in vitro culture tools for biomedical research by creating robust three-dimensional (3D) architecture to recapitulate the primary tissues' cellular heterogeneity, structure, and functions. Such organoid technology enables researchers to re-create human organs and diseases model in a culture dish. It thus holds excellent promises for many translational applications such as regenerative medicine, drug discovery, and precision medicine. This review summarizes the current knowledge on the progression and promotion of organoid models, particularly with the heart disease approach. We discuss the usefulness of clinical applications of cardiac organoids and ultimately highlight the currently advanced therapeutic strategies in vitro model of organoids aimed at personalizing heart disease treatment.

Address: Medical Laboratory Techniques Department, Al-Maarif University College, Al-Anbar-Ramadi, Iraq.; Institute of Pharmacy, Sechenov First Moscow State Medical University, 8 Trubetskaya St., bldg. 2, Moscow, 119991, Russian Federation.; Laboratory of Food Chemistry, Federal Research Center of Nutrition, Biotechnology and Food Safety, 2/14 Ustyinsky pr., Moscow, 109240, Russian Federation.; Faculty of Nursing, HRH Princess Chulabhorn College of Medical Science, Chulabhorn Royal Academy, Bangkok, 10210, Thailand.; Department of Clinical Pharmacy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Alkharj, Kingdom of Saudi Arabia.; Faculty of Nusring, Al-Nisour University College, Baghdad, Iraq.; Glocal School of Pharmacy, Glocal University, Saharanpur, Uttar Pradesh, India.; Department of Occupational Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, 50200, Thailand.; Department of Pharmacology, Saveetha Dental College, Saveetha Institute of Medical and Technical Science, Saveetha University, Chennai, India.

DOI: 10.2174/0929867330666221021122603

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MeSH Terms: Humans, Regenerative Medicine, Organoids, Biomedical Research, Heart, Heart Diseases