Glomerulonephritis Secondary to Acute Promyelocytic Leukemia that Resolved after Induction Therapy.

Carlos Andrés Regino, José Domingo Torres, Camilo Cáceres Galvis, Huxlhey Braulio Cabrera, Miguel Ángel Sanz

Journal: Acta haematologica 2023;146(3):240-244

PMID: 36538909

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Abstract

The association of glomerulonephritis and malignant hematological disease is uncommon, but well known in chronic leukemias, lymphomas, and monoclonal gammopathies. However, only a few cases of glomerulonephritis and acute myeloid leukemia have been reported in the literature. We describe the first case of a genetically diagnosed acute promyelocytic leukemia presenting with nephrotic range proteinuria that resolved with induction therapy with ATRA and ATO and performed a comprehensive review of the literature.

Address: Internal Medicine, Hospital Alma Mater de Antioquia, Medellín, Colombia.; Department of Hematology, Hospital San Vicente Fundación, University of Antioquia, Medellín, Colombia.; Thrombosis Group, University of Antioquia, Medellín, Colombia.; Department of Internal Medicine and medical oncology, Instituto Nacional de Cancerología - ESE, El Bosque University, Bogotá, Colombia, [email protected].; Department of Hematology, University of Antioquia, Medellín, Colombia.; Instituto de Investigación Sanitaria La Fe, Valencia, Spain.

DOI: 10.1159/000528088

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MeSH Terms: Humans, Leukemia, Promyelocytic, Acute, Tretinoin, Induction Chemotherapy, Antineoplastic Combined Chemotherapy Protocols, Glomerulonephritis, Oxides, Arsenicals