Chrysin Effect Against Gastric Cancer: Focus on its Molecular Mechanisms.

Seyyed Mohammad Matin Alavi Dana, Tahereh Farkhondeh, Michael Aschner, Majid Darroudi, Helia Samini, Saeed Samarghandian

Journal: Current molecular pharmacology 2023;16(7):707-711

PMID: 36597606

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Abstract

Gastric cancer is one of the most prevalent cancers in the world. Various therapeutic modalities have been used for its treatment, but all exhibit severe side effects, establishing the need for novel approaches. Chrysin is a phytomedicine compound belonging to the flavonoid group. It is found in honey and many plants. Its antitumor effects have been documented against gastric cancer cell lines in vitro, establishing its effects are mediated via different pathways and the expression of miRNA. In this review, we summarize the available literature on chrysin and its effects on gastric cancer, focusing on the cellular mechanisms it targets.

Address: Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.; Department of Toxicology and Pharmacology, School of Pharmacy, Birjand University of Medical Sciences, Birjand, Iran.; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Forchheimer 2091300 Morris Park Avenue, Bronx, New York, USA.; Department of Basic Sciences, Neyshabur University of Medical Sciences, Neyshabur, Iran.; Dentistry Student of Mashhad Medical University, Mashhad, Iran.; Healthy Ageing Research Centre, Neyshabur University of Medical Sciences, Neyshabur, Iran.

DOI: 10.2174/1874467216666230103105725

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MeSH Terms: Humans, Stomach Neoplasms, Cell Line, Tumor, Flavonoids, MicroRNAs