Neurotransmitters Regulation and Food Intake: The Role of Dietary Sources in Neurotransmission.

Amin Gasmi, Asma Gasmi Benahmed, Geir Bjørklund, Salvatore Chirumbolo, Lyudmila Pivina, Alain Menzel, Sadaf Noor, Massimiliano Peana, Aniqa Nasreen

Journal: Molecules (Basel, Switzerland) 2023;28(1):210

PMID: 36615404

Abstract

Neurotransmitters (NTs) are biologically active chemicals, which mediate the electrochemical transmission between neurons. NTs control numerous organic functions particularly crucial for life, including movement, emotional responses, and the physical ability to feel pleasure and pain. These molecules are synthesized from simple, very common precursors. Many types of NTs have both excitatory and inhibitory effects. Neurotransmitters' imbalance can cause many diseases and disorders, such as Parkinson's disease, depression, insomnia, increased anxiety, memory loss, etc. Natural food sources containing NTs and/or their precursors would be a potential option to help maintain the balance of NTs to prevent brain and psychiatric disorders. The level of NTs could be influenced, therefore, by targeting dietary habits and nutritional regimens. The progressive implementation of nutritional approaches in clinical practice has made it necessary to infer more about some of the nutritional NTs in neuropsychiatry. However, the importance of the intake of nutritional NTs requires further understanding, since there are no prior significant studies about their bioavailability, clinical significance, and effects on nerve cells. Interventional strategies supported by evidence should be encouraged.

Address: Société Francophone de Nutrithérapie et de Nutrigénétique Appliquée, 69100 Villeurbanne, France.; Department of Physiology, King Edward Medical University, Lahore 54000, Pakistan.; Laboratoires Réunis, 38, Rue Hiehl, L-6131 Junglinster, Luxembourg.; Académie Internationale de Médecine Dentaire Intégrative, 75000 Paris, France.; Department of Neurology, Ophthalmology and Otolaryngology, Semey Medical University, 071400 Semey, Kazakhstan.; CONEM Kazakhstan Environmental Health and Safety Research Group, Semey Medical University, 071400 Semey, Kazakhstan.; Institute of Molecular Biology and Biotechnology, Bahauddin Zakariya University, Multan 60800, Pakistan.; Department of Chemical, Physical, Mathematical and Natural Sciences, University of Sassari, Via Vienna 2, 07100 Sassari, Italy.; Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, 37134 Verona, Italy.; CONEM Scientific Secretary, Strada Le Grazie 9, 37134 Verona, Italy.; Council for Nutritional and Environmental Medicine, Toften 24, 8610 Mo i Rana, Norway.
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