Antimutagenic Activity as a Criterion of Potential Probiotic Properties.

Evgeniya V Prazdnova, Maria S Mazanko, Vladimir A Chistyakov, Anna A Bogdanova, Aleksandr G Refeld, Evgeniya Y Kharchenko, Michael L Chikindas

Journal: Probiotics and antimicrobial proteins 2022;14(6):1094-1109

PMID: 35028920

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Abstract

The antimutagenic activity of probiotic strains has been reported over several decades of studying the effects of probiotics. However, this activity is rarely considered an important criterion when choosing strains to produce probiotic preparations and functional food. Meanwhile, the association of antimutagenic activity with the prevention of oncological diseases, as well as with a decrease in the spread of resistant forms in the microbiota, indicates its importance for the selection of probiotics. Besides, an antimutagenic activity can be associated with probiotics' broader systemic effects, such as geroprotective activity. The main mechanisms of such effects are considered to be the binding of mutagens, the transformation of mutagens, and inhibition of the transformation of promutagens into antimutagens. Besides, we should consider the possibility of interaction of the microbiota with regulatory processes in eukaryotic cells, in particular, through the effect on mitochondria. This work aims to systematize data on the antimutagenic activity of probiotics and emphasize antimutagenic activity as a significant criterion for the selection of probiotic strains.

Address: Academy of Biology and Biotechnologies, Southern Federal University, Prospect Stachki, 194/1, Rostov-on-Don, Russia. [email protected].; Center for Agrobiotechnology, Don State Technical University, Rostov-on-Don, Russia. [email protected].; Academy of Biology and Biotechnologies, Southern Federal University, Prospect Stachki, 194/1, Rostov-on-Don, Russia.; Center for Agrobiotechnology, Don State Technical University, Rostov-on-Don, Russia.; Evolutionary Biomedicine Laboratory, SCAMT Institute, ITMO University, Saint Petersburg, Russia.; Cell Biophysics Laboratory, SCAMT Institute, ITMO University, Saint Petersburg, Russia.; Health Promoting Naturals Laboratory, School of Environmental and Biological Sciences, Rutgers State University, New Brunswick, NJ, USA.; I.M. Sechenov First Moscow State Medical University, Moscow, Russia.

DOI: 10.1007/s12602-021-09870-9

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https://dx.doi.org/10.1007/s12602-021-09870-9

MeSH Terms: Probiotics, Antimutagenic Agents, Mutagens, Microbiota