Manipulation of the bacterial flora in inflammatory bowel disease.

Fergus Shanahan, Philippe Seksik, Philippe Marteau

Journal: Best practice & research. Clinical gastroenterology 2003;17(1):47-61

PMID: 12617882

Full Text on Elsevier Science View on PubMed

Abstract

In this chapter we summarize the clinical and experimental data which indicate that bacteria, especially from the endogenous microflora, play a role in the pathogenesis of Crohn's disease, ulcerative colitis and pouchitis. We review the clinical trials, focusing on randomized controlled trials which used antibiotics or probiotics to treat situations of IBD or prevent recurrence, and we discuss the future of this approach.

Address: Gastroenterology Department, European Hospital Georges Pompidou, AP-HP & Paris V University, France.

DOI: 10.1053/bega.2002.0344

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MeSH Terms: Anti-Bacterial Agents, Antitubercular Agents, Ciprofloxacin, Enterobacteriaceae, Humans, Inflammatory Bowel Diseases, Nitroimidazoles, Pouchitis, Probiotics, Randomized Controlled Trials as Topic, Secondary Prevention