Management of Iron Deficiency in Heart Failure: A Review of Evidence.

Stormi E Gale, Bobbie Nguyen, Steven P Dunn, Erik Kellison, Emily F Gorman, Craig Beavers

Journal: Journal of cardiovascular pharmacology 2022;80(6):755-768

PMID: 36027595

Abstract

Iron deficiency is common in patients with heart failure and has been associated with worse outcomes, including increases in mortality, disease progression, and hospitalizations. As such, several studies have evaluated the role of iron supplementation in mitigating these risks. Evidence for the role of intravenous iron in improving exercise capacity, quality of life, and hospitalizations is promising, although the benefits of oral iron remain less clear. This review will evaluate the literature surrounding iron supplementation in heart failure and provide practical recommendations for its management.

Address: Novant Health, Matthews, NC.; University of Maryland School of Pharmacy, Baltimore, MD.; Department of Pharmacy, University of Virginia, Charlottesville, VA.; Virginia Mason Franciscan Health,Tacoma, WA.; Health Sciences and Human Services Library, University of Maryland, Baltimore, Baltimore, MD; and.; Division of Pharmacy Practice and Science, University of Kentucky, Lexington, KY.

DOI: 10.1097/FJC.0000000000001341

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MeSH Terms: Humans, Quality of Life, Iron Deficiencies, Heart Failure, Iron