Nanoplastics: Focus on the role of microRNAs and long non-coding RNAs.

Mina Homayoonfal, Zarrin Banikazemi, Mojgan Farshadi, Ali Rajabi, Nasrin Sharifi, Reza Sharafati Chaleshtori

Journal: Chemosphere 2022;308(Pt 1):136299

PMID: 36064029

Full Text on Elsevier Science View on PubMed

Abstract

When plastic objects in our surroundings are degraded, they may produce particles ranging in size from 1 to 100 nm therefore called nanoplastics. The environmental chemicals including nanoplastics may be able to affect biological processes in the nuclear level like altering DNA methylation and regulating microRNAs (miRNAs) as well as long non-coding RNAs (lncRNAs) expression and therefore are implicated in chronic human diseases like neoplasms. The regulatory role of miRNAs and lncRNAs in gene expression is appreciated. In vitro as well as in vivo experiments have shown that environmental elements including nanoplastics are able to dysregulate miRNAs and lncRNAs expression with possible genetic consequences that increase the risk of cancer development. In the current article, we review the biological effects of miRNAs and lncRNAs alterations following nanoplastics exposure.

Address: Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran; Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran.; Research and Development Center, Tehran University of Medical Sciences, Tehran, Iran.; Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran; School of Medicine, Kashan University of Medical Sciences, Kashan, Iran.; Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran.; Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran. Electronic address: [email protected].

DOI: 10.1016/j.chemosphere.2022.136299

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MeSH Terms: Humans, MicroRNAs, Microplastics, Neoplasms, RNA, Long Noncoding