Glucocorticoids and Water Balance: Implications for Hyponatremia Management and Pituitary Surgery.

Tony Goldschlager, Mendel Castle-Kirszbaum, Margaret D Y Shi, Peter J Fuller

Journal: Neuroendocrinology 2023;113(8):785-794

PMID: 37062279

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Abstract

Water balance is fundamental to all homeostasis. The hypothalamic-pituitary-adrenal axis influences water balance through the effects of corticotropin-releasing hormone and cortisol on arginine vasopressin secretion and the peripheral effects of cortisol on hemodynamics and renal water handling. In this review, we explored the complex interplay of glucocorticoids with water balance, with particular attention to hyponatremia and pituitary surgery.

Address: Department of Neurosurgery, Monash Health, Melbourne, Australia.; Department of Surgery, Monash University, Melbourne, Australia.; Barwon Health, Melbourne, Australia.; Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research, Melbourne, Australia.; Department of Molecular Translational Science, Monash University, Melbourne, Australia.

DOI: 10.1159/000530701

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MeSH Terms: Humans, Glucocorticoids, Hydrocortisone, Hypothalamo-Hypophyseal System, Adrenocorticotropic Hormone, Hyponatremia, Pituitary-Adrenal System, Corticotropin-Releasing Hormone