Cherubism in siblings: a case report.

Ravikiran Ongole, Rejeev S Pillai, Keerthilatha M Pai

Journal: Journal (Canadian Dental Association) 2003;69(3):150-4

PMID: 12622878

Free Full Text on Canadian Dental Association View on PubMed

Abstract

Cherubism is a non-neoplastic bone disease characterized by clinically evident bilateral, painless enlargements of the jaws that are said to give the patient a cherubic appearance. Cherubism may appear in solitary cases or in many members of the same family, often in multiple generations. On radiography, the lesions exhibit bilateral multilocular radiolucent areas. Histopathologic evaluation reveals proliferating fibrous connective tissue containing numerous multinucleated giant cells. Since the first description of this condition in 1933, almost 200 cases have been reported. We describe cherubism in 2 siblings and briefly review the literature on this subject.

Address: Department of Oral Medicine, Diagnosis and Radiology, College of Dental Surgery, Manipal 576119, India. [email protected]

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MeSH Terms: Adolescent, Alkaline Phosphatase, Calcium, Cherubism, Child, Chromosomes, Human, Pair 4, Diagnosis, Differential, Female, Fibrous Dysplasia of Bone, Humans, Hyperparathyroidism, Male, Mandibular Diseases, Phosphorus, Siblings